The rate of growth in our understanding of diseases of blood cells and coagulation proteins provides a challenge for the editors of a comprehensive textbook of hematology. The completion of the genome project and the acquisition of knowledge in the fields of genomics and proteomics, as applied to hematologic disorders, have accelerated the understanding of the pathogenesis of the diseases of our interest. The rate at which basic knowledge in molecular and cell biology and molecular immunology has been translated into improved diagnostic and therapeutic methods is equally as impressive. The vision of specific molecular targets for therapy has become a reality for some diseases and more is sure to come.
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